P-CARE will strengthen the collaboration between Italian and Austrian research institutes in the areas of genetics, biotechnology and the cancer clinics and generate a technical platform to investigate the mechanisms causing therapy resistance. Project goal is to gain a better understanding of the underlying  causes and, thus, increase the efficacy of cancer treatments.



The development of resistance to cancer therapy is one of the most frequent reasons for the failure of cancer treatments. Therapy resistance is linked to tumor-recurrence, with devastating consequences for the clinical outcome in the respective patients. It also represents a huge economic burden for public healthcare systems. The understanding of mechanisms causing therapy resistance, and the development of strategies directed towards the re-sensitization of resistant tumor cells to cancer therapy, represents one of the most important challenges to modern cancer research.

The project will develop a shared platform for the identification of drugs capable of re-sensitizing resistant tumors to conventional oncological treatments, through the repositioning of drugs already approved for the treatment of other pathologies. Furthermore, P-CARE will implement strategies of precision medicine, aiming to overcome resistance to anti-cancer immunotherapy by reproducing the immune response of the tumor-microenvironment in vitro. P-CARE will build an efficient trans-border network for sharing technology and knowledge that will be made accessible to academic and clinical cancer research in and outside the program area.

P-Care is funded by the European Union, the ERDF (European Regional Development Fund) and Interreg V-A Italia-Austria 2014-2020.

Total volume: 838,556.- Euro (ADSI 180,000.- Euro)

Duration: 2020 – 2023

Project partners:

  • UNITS Universita degli studi di Triest
  • UNIUD Universita degli studi di Udine
  • ADSI Austrian Drug Screening Institute GmbH
  • MUI Medizinische Universität Innsbruck
  • SABES Azienda Sanitaria dell’Alto Adige – Comprensorio sanitario di Bolzano
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